ANNOVERA is a ring-shaped vaginal system with hormones used by females to prevent pregnancy. Each cycle, you put it in yourself (and leave it in for 21 days), and you pull it out yourself (and leave it out for 7 days). Then repeat. ANNOVERA is a combination hormonal contraceptive, which means it has a couple of different kinds of hormones. ANNOVERA releases one of the lowest daily doses of ethinyl estradiol (0.013 mg/day) on the market and includes a new kind of progestin called segesterone acetate (0.15 mg/day). ANNOVERA continuously releases a low stream of these 2 hormones into your vagina, which then enter your blood.
Annovera can cause serious side effects, including: blood clots; toxic shock syndrome (TSS); liver problems, including liver tumors; high blood pressure; gallbladder problems; changes in the sugar and fat (cholesterol and triglycerides) levels in your blood; headache; irregular or unusual vaginal bleeding and spotting between your menstrual periods; depression; possible cancer in your cervix; swelling of your skin especially around your mouth, eyes, and in your throat (angioedema); dark patches of skin on your forehead, cheeks, upper lip, and chin (chloasma).
If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Symptoms of overdose may include severe nausea and vomiting, sudden/unusual vaginal bleeding.
If you have a history of breast cancer or other estrogen- or progestin-sensitive cancer, hepatic tumors, acute hepatitis, severe cirrhosis, undiagnosed abnormal uterine bleeding, and concomitant use of certain hepatitis C drug combinations. Cerebrovascular disease, coronary artery disease, DVT or PE, headaches, hypertension (uncontrolled), thrombogenic valvular or rhythm diseases of the heart, and females >35 years of age who smoke.